Pradefovir, a liver-targeted prodrug of adefovir against HBV infection
Tillmann, H.L.
Current Opinion in Investigational Drugs 8(8): 682-690
2007
ISSN/ISBN: 1472-4472 PMID: 17668370 Document Number: 614571
Metabasis Therapeutics Inc (previously Ribapharm Inc) is developing pradefovir, an oral liver-targeting prodrug of adefovir developed using its HepDirect technology, for the potential treatment of HBV infection. Phase II clinical trials of pradefovir have been completed.
Document emailed within 1 workday
Related Documents
2002: Adefovir (Hepsera) for chronic hepatitis B infection Medical Letter on Drugs and Therapeutics 44(1145): 105-106Medvedev, V.E.; Tarasiuk, B.A.; Medvetskiĭ, E.B.; Novikova, M.N.; Buchneva, L.V. 1984: Echography with targeted fine needle biopsy in the diagnosis of malignant tumors of the liver Klinicheskaia Khirurgiia 5: 23-25
Taéron, C. 2003: Adefovir Revue de l'Infirmiere 2003(95): 37-38
Mihaylova, Z.; Raynov, J. 2008: Neoadjuvant chemotherapy and targeted therapy in patients with liver metastases from colorectal cancer; medical oncologist's point of view Journal of Buon: Official Journal of the Balkan Union of Oncology 13(3): 323-331
Minami, M.; Okanoue, T. 2004: Antiviral treatment of chronic hepatitis B with adefovir dipivoxil Nihon Rinsho. Japanese Journal of Clinical Medicine 62(Suppl 8): 336-339
Lode, H.N.; Reisfeld, R.A.; Handgretinger, R.; Nicolaou, K.C.; Gaedicke, G.; Wrasidlo, W. 1998: Targeted therapy with a novel enediyene antibiotic calicheamicin theta(I)1 effectively suppresses growth and dissemination of liver metastases in a syngeneic model of murine neuroblastoma Cancer Research 58(14): 2925-2928
Loczenski, B. 2006: Hygiene in nursing--7: targeted prevention of infection in nursing homes Pflege Zeitschrift 59(1): 44-48
Sun, X-fang.; Zhang, H-bing.; Li, X-ping.; Xia, W-bo.; Xing, X-ping.; Meng, X-wu. 2011: A case of adefovir dipivoxil induced hypophosphataemic osteomalacia and literature review Zhonghua Nei Ke Za Zhi 50(9): 754-757
Kamp, W.; Schokker, J.; Cambridge, E.; De Jong, S.; Schuurman, R.; De Groot, T.; Boucher, C.A. 1999: Effect of weekly adefovir (PMEA) infusions on HIV-1 virus load: results of a phase I/Ii study Antiviral Therapy 4(2): 101-107
Mo, G.-s.; Wu, Z.-l.; Zhang, J.-l.; Hhang, Z.-g.; Cai, J.-g.; Jie, Z.-h.; Wu, X.-g.; Shi, J.-p. 2011: One-year combination therapy de novo of adefovir dipivoxil and lamivudine for decompensated cirrhosis related to HBV Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 25(2): 129-131
Rodriguez-Frias, F.; Jardi, R.; Schaper, M.; Buti, M.; Ferrer-Costa, C.; Tabernero, D.; Homs, M.; Esteban, R. 2008: Adefovir for chronic hepatitis B treatment: identification of virological markers linked to therapy response Antiviral Therapy 13(8): 991-999
Oliveira, S.A.N.; Hacker, M.A.; Oliveira, M.L.A.; Yoshida, C.F.T.; Telles, P.R.; Bastos, F.I. 2005: A window of opportunity: declining rates of hepatitis B virus infection among injection drug users in Rio de Janeiro, and prospects for targeted hepatitis B vaccination Revista Panamericana de Salud Publica 18(4-5): 271-277
Fung, J.; Lai, C.-L.; Yuen, J.C.-h.; Wong, D.K.-H.; Tanaka, Y.; Mizokami, M.; Yuen, M.-F. 2007: Adefovir dipivoxil monotherapy and combination therapy with lamivudine for the treatment of chronic hepatitis B in an Asian population Antiviral Therapy 12(1): 41-46
Junghanss, B.G. 1998: Increase in transaminases in HIV infection. Toxic liver cell damage with trimethoprim/sulfamethoxazole administration in HIV infection Praxis 87(10): 361-362
Zhang, D.; Zhao, G.; Li, L.; Li, Z. 2017: Observation of combined/optimized therapy of Lamivudine and Adefovir Dipivoxyl for hepatitis B-induced decompensated cirrhosis with baseline HBV DNA>1,000 IU/mL Acta Gastro-Enterologica Belgica 80(1): 9-13
Hokama, A.; Kinjo, F.; Saito, A. 1996: Endotoxin in Aeromonas sobria infection: speculative pathogenesis and treatment strategies in advanced liver disease with soft-tissue infection American Journal of Gastroenterology 91(7): 1475
Weckbecker, G.; Cory, J.G. 1987: 2,6-Diaminopurinedeoxyriboside as a prodrug of deoxyguanosine in L1210 cells Cancer Research 47(9): 2218-2223
Carrouée-Durantel, S.; Durantel, D.; Werle-Lapostolle, B.; Pichoud, C.; Naesens, L.; Neyts, J.; Trépo, C.; Zoulim, F. 2008: Suboptimal response to adefovir dipivoxil therapy for chronic hepatitis B in nucleoside-naive patients is not due to pre-existing drug-resistant mutants Antiviral Therapy 13(3): 381-388
Huba, G.J.; Melchior, L.A. 1998: A model for adolescent-targeted HIV/AIDS services: conclusions from 10 adolescent-targeted projects funded by the Special Projects of National Significance Program of the Health Resources and Services Administration Journal of Adolescent Health: Official Publication of the Society for Adolescent Medicine 23(2 Suppl): 11-27
Snydman, D.R.; Werner, B.G.; Dougherty, N.N.; Griffith, J.; Rohrer, R.H.; Freeman, R.; Jenkins, R.; Lewis, W.D.; O'Rourke, E. 1994: A further analysis of the use of cytomegalovirus immune globulin in orthotopic liver transplant patients at risk for primary infection. Boston Center for Liver Transplantation CMVIG-Study Group Transplantation Proceedings 26(5 Suppl 1: 23-27