Endometrial decidualization as a factor that regulates cytothrophoblastic invasion during the first trimester of pregnancy
Milovanov, A.P.; Fokina, T.V.; Starosvetskaia, N.A.; Nazimova, S.V.
Arkhiv Patologii 69(5): 31-34
2007
ISSN/ISBN: 0004-1955 PMID: 18074817 Document Number: 614328
Endometrial stromal cell decidualization is a multistage process that starts with the late secretory phase of a menstrual cycle and then continues in the first months of pregnancy. Under the influence of the hormone progesterone, precursor cells undergo a unique structural and functional transformation from the adventitional cells of spiral arteries containing a marker of smooth muscles (desmin) through pre-decidual cells to the decidual intermediate cells expressing a marker of the extraembryonic mesoderm (vimentin), and IGFBR-1 and then to the typical epithelioid decidual cells.