Expression of HOX C13 in odontogenic tumors
Hong, Y.-s.; Wang, J.; Liu, J.; Zhang, B.; Hou, L.; Zhong, M.
Shanghai Kou Qiang Yi Xue 16(6): 587-591
2007
ISSN/ISBN: 1006-7248 PMID: 18278407 Document Number: 614240
To study the expression of HOXC13 mRNA in odontogenic tumors. HOXC13 mRNA was detected in 47 cases of ameloblastoma (AB), 3 cases of calcifying cystic odontogenic tumor (CCOT), 3 cases of ameloblastic fibroma (AF), 10 cases of keratocystic odontogenic tumor (KCOT) and 2 cases of calcifying epithelial odontogenic tumor (CEOT) by in situ hybridization, and 7 cases of normal oral mucosa were selected as control. SPSS10.0 software package was used for chi(2) test. HOXC13 mRNA was positively expressed in all odontogenic epithelium except AF. The positive ratios were 97.9% in AB, 100% in CCOT, 100% in CEOT, 70.0% in KCOT epithelium and 42.9% in the normal oral mucosa. There was significant difference among AB, KCOT and normal mucosa (chi(2)=21.665, P<0.001). The genesis and development of odontogenic tumors are related to the high expression of HOXC13. The expression of HOXC13 mRNA in the odontogenic lesions has heterogeneity.