Effects of subchronic exposure to a 1439 MHz electromagnetic field on the microcirculatory parameters in rat brain
Masuda, H.; Ushiyama, A.; Hirota, S.; Wake, K.; Watanabe, S.; Yamanaka, Y.; Taki, M.; Ohkubo, C.
In Vivo 21(4): 563-570
2007
ISSN/ISBN: 0258-851X PMID: 17708347 Document Number: 614229
The aim of this study was to investigate whether repeated exposure to radio frequency electromagnetic field (RF EMF) of 1439 MHz affects the cerebral microcirculation, including blood-brain barrier function, in a rat brain. Materials and Methods: The head of the rat was exposed for four weeks (60 min/day, 5 days/week) to RF-EMF at 2.4 W/kg of brain averaged specific absorption rate (BASAR). Three microcirculatory parameters: blood-brain barrier permeability, leukocyte behavior and plasma velocity were measured before and after RF-EMF exposure using a closed cranial window method. Results: No extravasation of intravenously injected dyes from pial venules was found at any BASAR level. No significant changes in the number of endothelial-adhering leukocytes after exposure were found. The plasma velocity remained constant within the physiological range through each exposure. Conclusion: These findings suggest that there were no effects on the cerebral microcirculation under the given RF-EMF exposure conditions.