Molecular cytogenetic analysis of chromosome aberrations in desmoid tumors
Mayer, M.; Kulig, A.; Sygut, J.; Dziki, A.; Simon, D.; Latos-Bieleńska, A.; Ferenc, T.
Polish Journal of Pathology Official Journal of the Polish Society of Pathologists 58(3): 167-171
2007
ISSN/ISBN: 1233-9687 PMID: 18074861 Document Number: 614026
To date there are only few reports concerning chromosomal changes in desmoid tumors. To extend the knowledge in this field we examined 19 samples from the patients diagnosed with desmoid tumors. In the present study formalin-fixed and paraffin-embedded desmoid tumors were analyzed using fluorescence in situ hybridization (FISH) with alpha-satellite probes for chromosomes X, Y, 8 and 20. Chromosomal abnormalities were found in 6 cases, both abdominal and extra-abdominal tumors. FISH studies revealed one case of trisomy 8 and trisomy 20. In four patients we have identified monosomy 20. Our findings confirm earlier reports concerning the diversity of chromosomal changes in desmoid tumors and might suggest that both groups of abdominal and extra-abdominal tumors are genuine neoplasms.