Frequency of the Pro 12Ala polymorphism of PPARgamma2 gene in Ukrainian population and its possible role in development of metabolic syndrome
Kaĭdashev, I.P.; Rasin, A.M.; Shlykova, O.A.; Gorbas', I.M.; Smirnova, I.P.; Petrushov, A.V.; Rasin, M.S.
TSitologiia i genetika 41(5): 43-47
2007
ISSN/ISBN: 0564-3783 PMID: 18268966 Document Number: 613885
Frequency of the Pro 12Ala gene polymorphism PPARg2 has been studied in 39 healthy men and 42 men with metabolic syndrome (MS) of the age of 40-65 years in Ukrainian population. The frequencies were 27.9% for 12Ala allele, 32.6% for Pro12Ala, and 4.4% for Ala1Ala that is close to the results of estimation of Czech population. The frequency of 12Ala allele was significantly less--18.4% (p < 0.05) in the persons with MS that corresponds to the pre-established information concerning the patients with diabetes of the 2nd type. A tendency has been detected to the increase of the body mass index in patients with 12Ala allele in the metabolic syndrome group.