Subclinical hypothyroidism: a cardiovascular risk factor?
Cohen-Aubart, F.; Jublanc, C.; Chiche, F.; Bruckert, E.
Archives des Maladies du Coeur et des Vaisseaux 100(3): 213-216
2007
ISSN/ISBN: 0003-9683 PMID: 17536425 Document Number: 613823
Although patent hypothyroidism is clearly associated with increased cardiovascular risk, the relationship between infraclinical hypothyroidism and cardiovascular disease remains controversial though probable. This relationship is mediated by the traditional risk factors (lipids, hypertension), by changes in parameters of inflammation and haemostasis, and by a direct effect of thyroid hormones on the vessel wall. The authors review the epidemiological evidence and the mechanisms underlying the association between infraclinical hypothyroidism and cardiovascular risk and the therapeutic implications of this association.