Preoperative peripheral naïve / memory ratio and prognosis of nonsmall-cell lung cancer patients
Hara, M.; Matsuzaki, Y.; Shimizu, T.; Tomita, M.; Ayabe, T.; Enomoto, Y.; Onitsuka, T.
Annals of Thoracic and Cardiovascular Surgery Official Journal of the Association of Thoracic and Cardiovascular Surgeons of Asia 13(6): 384-390
2007
ISSN/ISBN: 1341-1098 PMID: 18292720 Document Number: 613628
This study focused on the relationship between preoperative peripheral blood CD4(+) naïve/memory ratio and prognosis following surgery for patients with nonsmall-cell lung cancer. After measuring CD3, CD4, CD8, CD45RA, CD45RO, CD25, and intracellular CTLA4 levels, CD4(+) naïve/memory ratios were determined for 13 controls and 38 patients. Although we observed no significant difference in the ratios, the patients exhibited a wider range of values than the controls. Of the 38 patients, 24 subsequently underwent surgery and were divided into three groups based on their preoperative CD4(+) naïve/memory ratio: Group I: <0.3; Group II: 0.3-0.8; and Group III: >0.8. Survival times were then evaluated. Group II survival was significantly better than Groups I and III. Our data suggest that the preoperative CD4(+) naïve/memory ratio may serve as a prognostic factor for nonsmall-cell lung cancer patients.