Effect of resveratrol on heart function of rats with adriamycin-induced heart failure
Wang, G.-y.; Wang, Y.-m.; Zhang, L.-n.; Li, Q.; Yue, H.; Song, C.-m.; Feng, J.-k.; Wang, N.
Zhongguo Zhong Yao Za Zhi 32(15): 1563-1565
2007
ISSN/ISBN: 1001-5302 PMID: 17972590 Document Number: 612173
To observe the protective effects of resveratrol (RES) on the heart function of the rats with adriamycin-induced heart failure. Thirty adult male SD rats were randomly divided into 5 groups: normal control (NC) group, adriamycin (ADR) group, RESL + ADR group, RES(H) + ADR group and RES group. RES of 30, 120, 120 mg x kg(-1) x d(-1) was given intraperitoneally (ip) once a day for 3 days in RES(L) + ADR group, RES(H) + ADR group and RES group respectively. The other two groups were given the same amount of normal saline the same way. On the 4h day,ADR of 10 mg x kg(-1) was given intraperitoneally once to induce myocardium injury model. After twenty-four hours, the pathological and biochemical changes of the myocardium were examined. As compared with NC group, the MDA, NO and NOS of the ADR group were significantly higher (P < 0.05), and the SOD of the ADR group were markedly lower (P < 0.05). As compared with ADR group, the indexes in RES(L) + ADR group, RES(H) + ADR group were exactly opposing, and took on dose dependance (P < 0.05). Light microscopic morphometry of the heart samples of the rats in ADR + RES(L, H) groups revealed typical diminishing of damage. RES can relieve the toxic effects of ADR on myocardium, and the cardioprotective effects may be correlated with its antioxidant activity and downregulation of NO.