TGF-beta signaling and aplasia cutis congenita: proposed animal model
Zehnaly, A.; Hosokawa, R.; Urata, M.; Chai, Y.
Journal of the California Dental Association 35(12): 865-869
2007
ISSN/ISBN: 1043-2256 PMID: 18240750 Document Number: 611436
TGF-beta plays a role in cell migration, proliferation, and differentiation during embryonic development. This study investigated the effect of neural crest- or mesodermspecific loss of TGF-beta type II receptor in mice. These conditional knockout mice both exhibit skin defects of the skull associated with an underlying bone defect, a phenotype consistent with the human disorder aplasia cutis congenita. The authors suggest that TGF-3 type II receptor gene is a candidate gene for aplasia cutis congenita.