Recent advances in neuroproteomics
Andrade, E.C.; Krueger, D.D.; Nairn, A.C.
Current Opinion in Molecular Therapeutics 9(3): 270-281
2007
ISSN/ISBN: 1464-8431 PMID: 17608026 Document Number: 611131
The last few years have seen a rapid growth in the use of proteomic methods to study normal brain function. In addition, such methods have been used to analyze changes in protein expression associated with the onset and progression of neuronal disease. The field of neuroproteomics faces special challenges given the complex cellular and sub-cellular architecture of the central nervous system. This article presents a review of recent progress in studies of neuroproteomics, and highlights the strengths and limitations of current proteomic profiling technologies used in studies of neuronal protein expression.