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Carbohydrate metabolism and aging--controversy of etiopathogenesis and pathophysiology. Part I. Changes of insulin sensitivity

Sokup, A.; Swiatkowski, M.

Wiadomosci Lekarskie 60(7-8): 386-389

2007

ISSN/ISBN: 0043-5147
PMID: 18175561
Document Number: 611083
Insulin resistance is one of the reasons of increasing carbohydrate metabolism disturbances with aging. Mechanisms of these changes had been partially elucidated. Decreasing of physical activity with increasing of total and abdominal fat are especially important pathogenetic mechanisms. Changes in glucose transporter 4 (GLUT-4) level in skeletal muscles and serum level of insulin like growth factor 1 (IGF-1) could be mechanisms independent of fat tissue. Other mechanisms which could be associated with insulin resistance in aging are related to leptin and adiponectin serum level or changes in mitochondrial energy metabolism and level of advanced glucose end products in diet.

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