Small cell cancer of the anal canal--case report of a rare tumor
Meyer, A.; Bruns, F.; Richter, K.; Grünwald, V.; Karstens, J.H.
Anticancer Research 27(2): 1047-1050
2007
ISSN/ISBN: 0250-7005 PMID: 17465242 Document Number: 610931
Background: We report on a rare case of small cell cancer located at the anal canal. Case report: A 41-year old woman presented with locally advanced small cell anal cancer and simultaneous hepatic and pulmonal deposits. Due to metastatic disease, chemotherapy with etoposide and cisplatin was performed with mixed response after four cycles of chemotherapy. After application of two additional chemotherapy cycles, locally progressive disease occurred causing symptomatic bowel obstruction. Pelvic irradiation was started and, several days later, additional irradiation of cerebral metastases was initiated due to rapid progression of distant disease. Despite adequate local treatment the patient's condition further deteriorated and irradiation was stopped. The patient died 10 months after initial diagnosis due to rapid tumor progression. Conclusion: Inpatients with metastatic small cell anal cancer chemotherapy remains the mainstay of therapy. Radiotherapy exerts additional activity and remains a prime choice to gain local control and ameliorate symptoms. Careful histopathological examination, together with immunohistochemistry, is needed to determine the therapeutic strategy to be followed.