Pulse pressure, arterial compliance and Buckberg index in hypertensive patients treated with nebivolol and nitrates
Prisadă, O.V.; Covic, A.; Arghiri, E.; Cernomaz, A.; Ungureanu, G.
Revista Medico-Chirurgicala a Societatii de Medici Si Naturalisti Din Iasi 111(2): 352-357
2007
ISSN/ISBN: 0048-7848 PMID: 17983167 Document Number: 610892
To evaluate the effect of nebivolol and nitrate administration on the arterial compliance--an essential factor for left ventricular hypertrophy regression. The arterial compliance was assessed in 32 hypertensive patients (mean age 52.3 years +/- 11, M/F ratio = 26/6) before drug administration, three hour post oral intake of nebivolol 5 mg and five minutes after sublingual 0.5 mg nitroglycerin. mean aortic blood pressure (PAom), pulse pressure (PP), augmentation index (AGIx) and Buckberg index (diastolic pressure-time index/systolic pressure-time index). The statistical significance of the results was determined by means of t-Student test. After nebivolol: PAom decreased from 131.2 +/- 15 mmHg to 118 +/- 15.3 mmHg; PP decreased from 72.5 +/- 12 mmHg to 52.3 +/- 11.3 mmHg; AG decreased from 17 to 10.2 mmHg, AGIx decreased from 26.4% to 22.3%, Buckberg index increased from 145.4 +/- 25% to 161.4 +/- 30%. After nitroglycerin: PAom decreased to 108.5 +/- 12 mmHg; PP decreased to 41.2 +/- 9.3 mmHg; AG decreased to 2.3 mmHg, AGIx decreased to 3.6%, Buckberg index increased to 171.2 +/- 32%. Nebivolol and nitrates determined a significant lowering of mean aortic pressure and an increase of the arterial compliance suggesting a beneficial effect that could promote the regression of left ventricular hypertrophy.