Ghrelin and sleep
Micić, D.; Susić, V.; Kostić, V.
GLAS. Srpska Akademija Nauka i Umetnosti. Odeljenje Medicinskih Nauka 49: 77-82
2007
ISSN/ISBN: 0371-4039 PMID: 18069356 Document Number: 610779
Human sleep is characterized by cycling of non-rapid-eye-movement sleep (NREMS) and rapid-eye-movement sleep (REMS) during which the secretion of different hormones has certain characteristics. During the first half of the night there is characteristic increase in growth hormone and at the same time decrease in ACTH and cortisole. Conversely, in the second part of the night there is an increase in ACTH and cortisole and the secretion of growth hormone is decreased. These facts indicate that there exist a reciprocal interaction of the hypothalamo-pituitary-somatotrophic axis and hypothalamo-pituitary-adrenal axis on one side and a common regulatory factors for EEG changes during sleep and nocturnal hormone secretion on the other. It follows that the reciprocal interaction of two key hormones of the hypothalamo-pituitary-somatotrophic axis (GHRH) and hypothalamo-pituitary-adrenal axis (CRH) have a fundamental role in the regulation of sleep.