Drug evaluation: OPT-80, a narrow-spectrum macrocyclic antibiotic
Johnson, A.P.
Current Opinion in Investigational Drugs 8(2): 168-173
2007
ISSN/ISBN: 1472-4472 PMID: 17328233 Document Number: 610710
Optimer Pharmaceuticals Inc, in collaboration with Par Pharmaceutical Companies Inc, is developing OPT-80, a narrow-spectrum macrocyclic antibiotic secreted by the actinomycete Dactylosporangium aurantiacum, for the potential treatment of Clostridium difficile-associated diarrhea (CDAD) and vancomycin-resistant Enterococcus infection. A phase IIb/III clinical trial of OPT-80 in patients with CDAD is underway.
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