Mercury toxicity: trace element interactions and detoxification activity by L-arginine
Santarelli, L.; Piacenza, F.; Bonacucina, V.; Malavolta, M.; Mocchegiani, E.; Bracci, M.
Giornale Italiano di Medicina del Lavoro Ed Ergonomia 29(3 Suppl): 534-536
2007
ISSN/ISBN: 1592-7830 PMID: 18409817 Document Number: 610207
Mercury (Hg) exposure makes happen disease to humans and animals spreading in all body compartments, especially in liver and kidney. In these ones, copper, zinc, manganese and iron were investigated to assess perturbation of essential metals' homeostasis due to Hg chronic intoxication. Because L-arginine, is able to induce beneficial influence on immunologic functions on mice intoxicated with Hg, we also studied the efficiency of detoxification process before and after treatment with this aminoacid. Adding L-arginine to diet of the intoxicated mice we achieved a good restoration to normal homeostatic conditions.