A simple HPLC-UV method for the determination of dimenhydrinate and related substances--dentification of an unknown impurity
Döge, U.; Eger, K.
Die Pharmazie 62(3): 174-178
2007
ISSN/ISBN: 0031-7144 PMID: 17416192 Document Number: 609966
During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.