Advances in therapeutic strategies for multiple myeloma
Miwa, A.
Gan to Kagaku Ryoho. Cancer and ChemoTherapy 34(13): 2200-2216
2007
ISSN/ISBN: 0385-0684 PMID: 18079620 Document Number: 609245
Multiple myeloma (MM) remains an incurable plasma cell dyscrasia characterized by bone marrow failure, bone disease, renal disease and other complications. The clinical pictures show extensive diversity which is based on complex cytogenetic abnormalities, and lot of interactions between myeloma cell and bone marrow stroma. Recently, advances in understanding the biology of myeloma including the function of proteasome, molecular chaperons on the folding of intracellular proteins as well as signal transduction pathway, apoptosis-inducing cascade and oncogenomics, have brought about the development of several new therapeutic strategies. This review summarizes the major innovative agents in this field and discuss the future directions.