Contemporary molecular-biological methods of cancer diagnosis and monitoring based on the humoral immune response to tumor-associated antigens
Shebzukhov, I.V.; Belousov, P.V.; Khlgatian, S.V.; Sazykin, A.Iu.; Kuprash, D.V.; Nedospasov, S.A.
Molekuliarnaia Genetika Mikrobiologiia i Virusologiia 2007(2): 3-6
2007
ISSN/ISBN: 0208-0613 PMID: 17600920 Document Number: 609105
Humoral immune response to tumor-associated antigens in cancer patients can be used as a basis for disease diagnosis and monitoring. Moreover, identification of molecular targets of such response may be used to develop antigen-specific anticancer vaccines. Here, we review the main approaches to identification and study of tumor-associated antigens recognized by serum antibodies. We also focus on the challenges that must be met before serological antigens can be used in clinical cancer diagnostics.