Perioperative changes of the coagulation markers in patients undergoing hip fracture surgery
Okamura, K.; Nakagawa, I.; Hidaka, S.; Okada, Y.; Kubo, T.; Kato, T.
Masui. Japanese Journal of Anesthesiology 56(11): 1353-1357
2007
ISSN/ISBN: 0021-4892 PMID: 18027607 Document Number: 607969
Plasma levels of D-dimer, fibrin monomer complex (FMC) and FDP were measured in 10 patients who underwent hip fracture surgery, using a recently established monoclonal antibody to clarify if these markers are good indicators of deep vein thrombosis (DVT). Subjects were 10 (4 male and 6 female) hip fracture patients, aged 87 +/- 6 years. D-dimer, FMC and FDP were measured at induction of anesthesia and 24 hours as well as 6 days after operation. Preoperative values of D-dimer, FMC and FDP were higher than normal values, and these markers remained high during the postoperative period. It is concluded that plasma levels of D-dimer, FMC and FDP in the patients with hip fracture were high in perioperative period. Among these markers, FMC was the most useful indicator for the diagnosis at the early stage of DVT.