Prognostic significance of microvessel density in ovarian cancer
Rossochacka-Rostalska, B.; Gisterek, I.J.; Suder, E.; Szelachowska, J.K.; Matkowski, R.A.; Lacko, A.; Kornafel, J.A.
Wiadomosci Lekarskie 60(3-4): 129-137
2007
ISSN/ISBN: 0043-5147 PMID: 17726864 Document Number: 606596
The antigen of endothelial cell which are the exponent of microvessels density in cancer tumor as CD31, CD34 and CD105 are the most common analysed markers of angiogenesis. The aim of the work was to analyse the expression of CD31, CD34 and CD105 antigens--three basic markers of microvessel density in ovarian cancer. The material included 80 patients with ovarian carcinoma, treated between 1996 and 2001 in Department of Oncology Gynecology of Lower Silesian Centre of Oncology. The median of age was 54.4 years. Most of analyzed cases (n = 53) were serum ovarian carcinoma in III and IV FIGO stage. The correlations between microvessel density (MVD) and clinicopathological parameters were analyzed. We have stated that in patients younger than 50 years the microvessel density was lower. This correlation was statistically significant in the estimation of MVD by CD31 and CD34 expression and close to statistically significant by marked CD105 expression. In patients with time of menopause that occurred before 46 years of age, microvessel density marked with CD105 expression was significantly higher and close to significance in CD31 marker. Cox analysis proved that independent risk factors of death in patients with ovarian cancer were: age over 50 years, low degree of patient performance according to WHO (World Health Organization) scale, high FIGO (International Federation of Gynecology and Obstetrics) stage and high expression of CD34 microvessel density.