Efficacy and safety of lornoxicam in an early postoperative period
Nikoda, V.V.; Maiachkin, R.B.; Bondarenko, A.V.
Terapevticheskii Arkhiv 79(8): 28-33
2007
ISSN/ISBN: 0040-3660 PMID: 17926467 Document Number: 606467
Aim. To compare quality of anesthesia with opioid drug and nonsteroid anti-inflammatory drugs in 123 patients after extensive operative interventions of the lungs and trachea, abdominal organs, lower limbs.Material and methods. Patients of group I took lornoxicam for relief of postoperative pain syndrome, those of group 2-promedol. Quality of anesthesia was assessed by visual-analogue and verbal scales, day dose of analgetic drug, administration of promedol, side effects incidence.Results. Lornoxicam in a dose 8 mg intravenously has comparable with 20 mg promedol analgetic effect. This justifies its use as a basic analgetic for treatment of acute pain after extensive surgery. Lornoxicam allows surgeons to do without opioids in 10-45% patients or to reduce their dose by 32-65%.Conclusion. Adequate anesthesia with lornoxicam and promedol early after surgery on the chest and abdominal organs, major vessels of the lower limbs occurs in 82 and 87% patients, respectively. Lornoxicam administration as continuous intravenous infusion and controlled analgesia in older patients eliminates the need in opioid analgetics in 45% cases and is well tolerated.