Reactive oxygen species and vascular hyporeactivity in septic shock. Part II--scavengers and vascular hyporeactivity in septic shock
Gendzwiłł, A.
Polski Merkuriusz Lekarski Organ Polskiego Towarzystwa Lekarskiego 23(136): 284-287
2007
ISSN/ISBN: 1426-9686 PMID: 18293852 Document Number: 606243
Reactive oxygen species (ROS) are formed as a result of physiologic cellular metabolism and although they are essential for signalization they also, when produced in excess, contribute to the pathogenesis of many diseases. This paper is an attempt to summarize the role of ROS in the development of septic shock. At the beginning scavengers that counteract the excessive action of ROS are discussed. In the next part, the problem of how the presence of lipopolysaccharide changes the cellular metabolism into production of proinflammatory agents, leading to the patient's death, is discussed.