Anthracycline-based adjuvant chemotherapy in early-stage uterine sarcomas: long-term results of a single institution experience
Papadimitriou, C.A.; Zorzou, M.P.; Markaki, S.; Rodolakis, A.; Voulgaris, Z.; Bozas, G.; Kastritis, E.; Bamias, A.; Gika, D.; Dimopoulos, M.A.
European Journal of Gynaecological Oncology 28(2): 109-116
2007
ISSN/ISBN: 0392-2936 PMID: 17479671 Document Number: 606113
Purpose of investigation: Uterine sarcomas are rare neoplasms characterized by a high rate of local recurrences and distant metastases. The role of chemotherapy in early-stage completely resected disease remains controversial.Methods: Thirty-one patients with Stage I or II uterine sarcomas, referred to our center for adjuvant chemotherapy, received anthracycline-based regimens. Seventeen (54.8%) patients received ifoslamide, etoposide and epirubicin, six (19.4%) were treated with doxorubicin and carboplatin, three (9.6%) were administered doxorubicin and ifosfamide, while five (16.1%) patients received various anthracycline-based regimens.Results: With a median follow-up of 82 months disease recurred in 12 (38.7%) patients. Five-year survival probability is estimated at 54%. Both median overall survival and time to progression for all patients have not been reached yet. Patients who received ifosfamide-containing regimens had a statistically significant benefit in overall survival (p <= 0.05) when compared with those treated with non-ifosfamide-containing regimens.Conclusion: Our data suggest a potential role for anthracycline- and ifosfamide-containing chemotherapy in the adjuvant setting for early-stage uterine sarcomas.