Acquired AmpC type beta-lactamases: an emerging problem in Italian long-term care and rehabilitation facilities
Migliavacca, R.; Nucleo, E.; D'Andrea, M.M.; Spalla, M.; Giani, T.; Pagani, L.
New Microbiologica 30(3): 295-298
2007
ISSN/ISBN: 1121-7138 PMID: 17802913 Document Number: 606011
We report the multiple detection of Proteus mirabilis isolates, from 4 different long-term care and rehabilitation facilities (LTCRFs) of Northern Italy, resistant to expanded-spectrum cephalosporins and cephamycins and producing an acquired ampC-like beta-lactamase, named CMY-16. Genotyping by PFGE showed that isolates were clonally related to each other, although not identical. In all isolates the bla(CMY-16) gene was not transferable by conjugation and was found to be carried on the chromosome, These results revealed multifocal spreading of a CMY-16 producing P. mirabilis clone in Northern Italy and emphasize the emergence of similar acquired resistance determinants in the LTCRFs setting.