Interstitial lung disease as the first manifestation of systemic sclerosis
van der Kamp, R.; Tak, P.P.; Jansen, H.M.; Bresser, P.
Netherlands Journal of Medicine 65(10): 390-394
2007
ISSN/ISBN: 0300-2977 PMID: 18057462 Document Number: 606006
We describe three patients with progressive fibrosing interstitial lung disease (ILD) as the first and only manifestation of systemic sclerosis. In one patient the presence of anti-Scl-70 autoantibodies suggested systemic sclerosis to be the underlying cause of the disease. In the two other subjects, however, anti-Scl-70 antibodies were negative. in these patients the lung disease preceded other manifestations of systemic sclerosis by several years. Diagnosis, prognosis and treatment of systemic sclerosis-associated ILD is discussed.
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