Peripheral neuropathy in systemic lupus erythematosus with epineural vasculitis and antiphospholipid antibodies
Rafai, M.A.; Fadel, H.; Boulaajaj, F.Z.; Gam, I.; El-Moutawakkil, B.; Karkouri, M.; Hakim, K.; Slassi, I.
Revue Neurologique (Paris) 163(1): 103-106
2007
ISSN/ISBN: 0035-3787 PMID: 17304181 Document Number: 605824
Neurological manifestations of systemic lupus erythematosus are frequent and polymorphic. Their frequency varies according to authors (24-75p.cent). Central nervous system complications predominate; peripheral features are rare, classically symmetrical polyneuropathy, multiple mononeuropathies or cranial nerve involvement. We report a case of a 48-year-old woman presenting a histologically documented sensitivo-motor polyneuropathy with severe motor involvement complicating lupus associated with antiphospholipides antibodies. Outcome was good after cyclophosphamid pulse. We discuss the frequency of peripheral involvement in systemic lupus erythematosus, pathogenic mechanisms, therapeutic possibilities and outcome of this complication.