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2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces Leishmania major burdens in C57BL/6 mice

Bowers, O.J.; Sommersted, K.B.; Sowell, R.T.; Boling, G.E.; Hanneman, W.H.; Titus, R.G.; Dekrey, G.K.

American Journal of Tropical Medicine and Hygiene 75(4): 749-752

2006

ISSN/ISBN: 0002-9637
PMID: 17038706
Document Number: 604851
Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major-infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.

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