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Pyridinium, imidazolium and quinuclidinium compounds: toxicity and antidotal effects against the nerve agents Tabun and Soman

Reiner, E.; Simeon-Rudolf, V.

Arhiv Za Higijenu Rada i Toksikologiju 57(2): 171-179

2006

ISSN/ISBN: 0004-1254
PMID: 16832972
Document Number: 604375
This paper discusses the toxicity and antidotal effects of 32 compounds. Screening studies have shown that these compounds combined with atropine are effective antidotes against the organophosphate nerve agents Tabun and/or Soman, having a therapeutic factor equal or greater than 2.0 when tested in mice or rats. We analysed the results of these studies, and recommend that these compounds should be studied in more detail simultaneously with conventional antidotes (PAM-2, HI-6, Toxogonin, TMBA) in order to assess whether they could broaden the choice of compounds now available for the treatment of organophosphate poisoning.

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