Differential diagnosis of lymphadenopathy in HIV/AIDS
Pivnik, A.V.; Korovushkin, V.G.; Parkhomenko, V.N.; Tonkoglaz, V.N.; Pavlova, L.E.; Litivinova, N.G.; Peregudova, A.B.; Degterev, D.A.; Gruzdev, B.M.
Terapevticheskii Arkhiv 78(4): 28-32
2006
ISSN/ISBN: 0040-3660 PMID: 16821418 Document Number: 604357
Aim. To determine the role of histological diagnosis of lymphadenopathy (LAP) associated with clinico-laboratoty picture in patients with HI V infection/AIDS.Material and methods. Target biopsy of the peripheral lymph node was made in 80 HIV-infected patients from 2002 to 2005. Histological diagnosis was made in all the patients with light microscopy, in some patients at immunohistological examination.Results. Most of the patients had peripheral blood CD4 lymphocytes under 200 cell/mcl. Viral load was hundred thousands copies in mcl. Tuberculosis was diagnosed in 33 (41916) patients, lymphomas in 23(29%), lymphogranulomatosis - in 5 (6%), reactive lymphadenopathy - in 15 (19516), germinogenic tumors - in 3 (4%), sarcoidosis - in 1 (1%). Histologically, LAP was represented by follicular hyperplasia (n = 9), involution (n = 2), bacterial lymphadenitis with necrosis (n = 4).Conclusion. Biopsy of peripheral lymph nodes is an early, safe, reliable and cost-effective method of LAP diagnosis in patients with AIDS.