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Antitumor activity of SK-7041, a novel histone deacetylase inhibitor, in human lung and breast cancer cells

Lee, K-Wook.; Kim, J.Hyun.; Park, J-Hyun.; Kim, H-Phill.; Song, S-Hyun.; Kim, S.Gyun.; Kim, T.Young.; Jong, H-Soon.; Jung, K.Hae.; Im, S-Ah.; Kim, T-You.; Kim, N.Kyeong.; Bang, Y-Jue.

Anticancer Research 26(5a): 3429-3438

2006

ISSN/ISBN: 0250-7005
PMID: 17094463
Document Number: 604293
Background: A class of synthetic histone deacetylase (HDAC) inhibitors, which are hybrids of trichostatin A and MS-275 were previously developed. In this study, the antitumor effects of SK-7041, one of those novel HDAC inhibitors, was evaluated on lung and breast cancer cell lines. Materials and Methods: Human lung and breast cancer cells, as well as normal human bronchial epithelial (NHBE) cells were treated with SK-7041, and results were compared with those of cells treated with suberoylanilide hydroxamic acid (SAHA). Results: SK-7041 induced time-dependent histone hyperacetylation and showed more potent cytotoxicity than SAHA in cancer cells. These antiproliferative effects of SK-7041 were due to apoptotic cell death caused by G21M-phase arrest and to a lesser extent to G1 arrest. Moreover, SK-7041 inhibited cancer cell proliferation more selectively than NHBE cell proliferation. Conclusion: These results suggest that SK-7041 may have potential anticancer activity.

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Yang, X.; Ferguson, A.T.; Nass, S.J.; Phillips, D.L.; Butash, K.A.; Wang, S.M.; Herman, J.G.; Davidson, N.E. 2000: Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition Cancer Research 60(24): 6890-6894
Lee, E.J.; Lee, B.B.; Kim, S.-J.; Park, Y.-D.; Park, J.; Kim, D.-H. 2008: Histone deacetylase inhibitor scriptaid induces cell cycle arrest and epigenetic change in colon cancer cells International Journal of Oncology 33(4): 767-776
Pei, T.; Liu, F.; Deng, A.-p. 2016: Synthesis and anti-tumor activity of ciprofloxacin-histone deacetylase inhibitor conjugates Yao Xue Xue Bao 51(12): 1871-1880
Appelskog, I.B.; Ammerpohl, O.; Svechnikova, I.G.; Lui, W-O.; Almqvist, P.M.; Ekström, T.J. 2004: Histone deacetylase inhibitor 4-phenylbutyrate suppresses GAPDH mRNA expression in glioma cells International Journal of Oncology 24(6): 1419-1425
Shitikova, Z.V.; Aksenov, N.D.; Pospelov, V.A.; Pospelov, T.V. 2011: Cell senescence induced by histone deacetylase inhibitor sodium butyrate in rodent transformed cells resistant to apoptosis Tsitologiia 53(3): 277-284
Zhang, Z.-l.; Zhang, A.-h.; Feng, Z.-q.; An, L.; Zhao, Q.-h. 2013: Histone deacetylase inhibits the growth and migration of human osteosarcoma cells Zhonghua Yi Xue Za Zhi 93(33): 2680-2685
Burenkova, O.V.; Aleksandrova, E.A.; Zaraĭskaia, I.I. 2013: Gender-dependent effects of histone deacetylase inhibitor sodium valproate on early olfactory learning in 129Sv mice Rossiiskii Fiziologicheskii Zhurnal Imeni I.M. Sechenova 99(2): 212-220
Wei, M.; Wanibuchi, H.; Morimura, K.; Salim, E.I.; Moku, M.; Doi, K.; Mitsuhashi, M.; Masuda, C.; Shen, J.; Kinoshita, A.; Fukushima, S. 2004: Lack of preventive efficacy of FK228, a histone deacetylase inhibitor, against N-butyl-N-(4-hydroxybutyl) nitrosamine-induced urinary bladder carcinogenesis in p53+/- and p53+/+ mice Anticancer Research 24(2b): 785-790
Chuĭkin, I.A.; Lianguzova, M.S.; Pospelov, V.A. 2006: Anti-proliferative effect of histone deacetylase inhibitors on murine embryonic stem cells Tsitologiia 48(8): 674-683
Kuroiwa, S.; Koyama, M.; Watanabe, N.; Ekimoto, H.; Ohnishi, Y.; Saito, M.; Maruo, K.; Inaba, M.; Tashiro, T.; Yamori, T. 1993: Antitumor activity of a new antiestrogenic drug, toremifene (NK622) against human breast cancer xenografts in nude mice Gan to Kagaku Ryoho. Cancer and ChemoTherapy 20(5): 617-623
Oizumi, S.; Isobe, H.; Ogura, S.; Ishida, T.; Yamazaki, K.; Nishimura, M.; Kawakami, Y.; Dosaka-Akita, H. 2002: Topoisomerase inhibitor-induced apoptosis accompanied by down-regulation of Bcl-2 in human lung cancer cells Anticancer Research 22(6c): 4029-4037
Fujimoto, S.; Takahashi, M.; Kiuchi, S.; Kobayashi, K.; Mutou, T.; Masaoka, H.; Shimanskaya, R.B.; Ohkubo, H. 1994: Hyperthermia-induced antitumor activity in human gastric cancer cells serially transplanted into nude mice Anticancer Research 14(1a): 67-71
Kovalev, R.A.; Shtam, T.A.; Karelov, D.V.; Burdakov, V.S.; Volnitskiy, A.V.; Makarov, E.M.; Filatov, M.V. 2015: Histone deacetylase inhibitors cause the TP53-dependent induction of p21/Waf1 in tumor cells carrying mutations in TP53 Tsitologiia 57(3): 204-211
Hakulinen, J.; Meri, S. 1994: Expression and function of the complement membrane attack complex inhibitor protectin (CD59) on human breast cancer cells Laboratory Investigation; A Journal of Technical Methods and Pathology 71(6): 820-827
Bozeman, E.N.; Srivatsan, S.; Mohammadi, H.; Daniels, D.; Shashidharamurthy, R.; Selvaraj, P. 2012: Ukrain, a plant derived semi-synthetic compound, exerts antitumor effects against murine and human breast cancer and induce protective antitumor immunity in mice Experimental Oncology 34(4): 340-347
Li, J.; Wang, S.-X. 2016: Synergistic enhancement of the antitumor activity of 5-fluorouracil by bornyl acetate in SGC-7901 human gastric cancer cells and the determination of the underlying mechanism of action Journal of Buon: Official Journal of the Balkan Union of Oncology 21(1): 108-117
Beall, H.D.; Murphy, A.M.; Siegel, D.; Hargreaves, R.H.; Butler, J.; Ross, D. 1995: Nicotinamide adenine dinucleotide (phosphate): quinone oxidoreductase (DT-diaphorase) as a target for bioreductive antitumor quinones: quinone cytotoxicity and selectivity in human lung and breast cancer cell lines Molecular Pharmacology 48(3): 499-504
Zheng, J.; Wang, H.; Yao, J.; Zou, X. 2014: More antitumor efficacy of the PI3K inhibitor GDC-0941 in breast cancer with PIK3CA mutation or HER2 amplification status in vitro Die Pharmazie 69(1): 38-42
Chen, G.; Teicher, B.A.; Frei, E. 1996: Differential interactions of Pgp inhibitor thaliblastine with adriamycin, etoposide, taxol and anthrapyrazole CI941 in sensitive and multidrug-resistant human MCF-7 breast cancer cells Anticancer Research 16(6b): 3499-3505
Zhang, X.Q.; Yang, C.Y.; Rao, X.F.; Xiong, J.P. 2016: Plumbagin shows anti-cancer activity in human breast cancer cells by the upregulation of p53 and p21 and suppression of G1 cell cycle regulators European Journal of Gynaecological Oncology 37(1): 30-35