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Hemostatic system parameters of placental extracts in normal pregnancy and severe preeclampsia

López-Ramírez, Y.; Carvajal, Z.; Arocha-Piñango, C.L.

Investigacion Clinica 47(3): 233-240

2006

ISSN/ISBN: 0535-5133
PMID: 17672283
Document Number: 604259
To better understand the role of the hemostatic mechanism in preeclampsia, placental extracts obtained from 26 normal pregnant women (NP) and 12 patients with severe pre-eclampsia (SPE) were analyzed to determine thrombomodulin (TM), tissue factor (TF), tissue-type plasminogen activator (tPA), plasminogen activator inhibitor (PAI) 1 and 2, and TF pathway inhibitor (TFPI). The results showed similar concentrations of TF, TM and PAI-2 in both groups, while tPA increased no significantly and TFPI and PAI-1 increased significantly in SPE placentas.

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