Effects of hyperoxic gas mixtures on the proliferative and migrative activities of cultivated endothelial cells of humans
Buravkova, L.B.; Grinakovskaia, O.S.; Merzlikina, N.V.
Aviakosmicheskaia i Ekologicheskaia Meditsina 40(3): 38-42
2006
ISSN/ISBN: 0233-528X PMID: 17193968 Document Number: 603459
Proliferation and migration of endothelial cells of humans were studied in hyperoxic gas mixtures varying in percentage of oxygen and argon. Exposure to one or the other hyperoxic mixture was repeated, short (3 hrs) or long (18 hrs). The most significant inhibition of proliferation was observed after three long exposures in 100% O2 and the least signficant inhibition was caused by the gas mixture containing 89% of O2, 4.5% of Ar and 6.5% of N2 as an end-product of air separation with the short-cycle natural adsorption. Single 3-hr exposure to the hyperoxic mixture (5% Ar + 95% O2) activated EC migration, whereas repeated short exposure and single long exposure inhibited EC migration in vitro.