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The role of cyclooxygenase on angiogenesis and endothelial progenitor cell mobilization in rat ischemic myocardium

Zhou, J.; Huang, L.; Jin, J.; Wu, X.-j.; Fang, Y.-q.; Song, M.-b.; Zhao, G.; Zhao, X.-h.; Zhou, Y.-p.

Zhonghua Xin Xue Guan Bing Za Zhi 34(9): 833-836

2006

ISSN/ISBN: 0253-3758
PMID: 17217696
Document Number: 603074
To investigate the effect of COX1 and COX2 on angiogenesis and endothelial progenitor cell mobilization in rats with experimental myocardial infarction (MI). The rats were randomly divided into 3 groups: MI group, MI plus rofecoxib group and MI plus valeryl salicylate group. At the 7th day after operation, circulating EPCs, plasma VEGF and HIF-1alpha mRNA of ischemic myocardium were measured. At the 28th day post operation, capillary densities were also measured in ischemic myocardium. Compared with the MI group and the MI plus valeryl salicylate group, circulating EPCs, plasma VEGF, HIF-1alpha mRNA and capillary densities of ischemic myocardium were all decreased in MI plus rofecoxib group. The present study revealed that COX2 play an important role with angiogenesis and endothelial progenitor cell mobilization in rat with experimental MI by modulating expression of VEGF and HIF-1alpha.

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