Modelling epidermal homeostasis as an approach for clinical bioinformatics
Grabe, N.; Pommerencke, T.; Müller, D.; Huber, S.; Neuber, K.; Dickhaus, H.
Studies in Health Technology and Informatics 124: 105-110
2006
ISSN/ISBN: 0926-9630 PMID: 17108511 Document Number: 602311
Modelling in systems biology currently lacks clinical applications. As a possible approach leading to clinical relevance the modelling of tissue homeostasis is proposed. As an example a model of epidermal homeostasis is presented which reproduces central morphological and kinetic characteristics of epidermal tissue. Each individual cell is modelled as an agent. The tissue arises as an emergent phenomenon from the interactions of agents. Each agent's behaviour is qualitatively modelled by a simple differentiation state-flow program. Epithelialisation under the influence of parameters concerning stem-cell location is briefly demonstrated.