Immunophenotypic peculiarities of mobilized stem (CD34+) cells in blood from patients with severe spinal cord injury
Tupitsyn, N.N.; Yaryghin, V.N.; Bryukhovetskiy, A.S.; Grivtsova, L.Y.; Mentkevich, G.L.; Dolgopolov, I.S.; Zaitsev, A.Y.; Davydov, M.I.
Journal of Biological Regulators and Homeostatic Agents 20(1-2): 36-40
2006
ISSN/ISBN: 0393-974X PMID: 18088553 Document Number: 601800
Immunophenotype of mobilized stem blood cells (CD34+) was studied in 29 patients with late post-traumatic spinal lesions. The CD34+ cells demonstrated different levels of expression of CD45, CD38, monomorphic determinants HLA-DR and gp130 epitopes. Most patients presented with a CD34+ cell fraction with no or low expression of common leukocytic antigen CD45. Only 2 patients had greater than 15 percent of HLA-DR-CD38- cells in the CD34+ fraction. A common transducer molecule of interleukin-6 family cytokines gp130 was expressed on stem (CD34+) cells in all the cases, 26 percent of the patients had an activated gp130 phenotype, i.e. a combination of C7+ and A1- epitopes.