Variant genotyping of CCR2-64I, SDF1-3' a and CCR5Delta32 in HIV-1 infected Chinese long-term nonprogressors
Wang, S.-x.; Shang, H.; Han, X.-x.; Zhang, Z.-n.; Wang, Y.-n.; Zhang, M.; Jiang, Y.-j.; Liu, J.; Su, Y.-l.
Zhonghua Shi Yan he Lin Chuang Bing du Xue Za Zhi 20(1): 16-19
2006
ISSN/ISBN: 1003-9279 PMID: 16642210 Document Number: 601650
To investigate variant genotyping of CCR2-64I, SDF1-3'A and CCR5Delta32 in HIV-1 infected Chinese Long-term nonprogressors and to study their association with disease progression. The genotypes of CCR2-64I, SDF1-3'A and CCR5Delta32 were detected by polymerase chain reaction/restriction fragment length polymorphism (PCR/RFLP) assay in seventeen HIV-1 infected Chinese Long-term nonprogressors (LTNPs) and thirty-nine Chinese typical progressors (TPs). The frequency of CCR2-64I and SDF1-3'A in LTNPs are 50% and 62.5%, higher than those (23.08% and 33.33%) in TPs. Only one heterozygous CCR5 mutant was detected in LTNPs, and no CCR5 mutant in TPs. Variant genotyping of CCR2-64ISDF1-3'A and CCR5Delta32 may be protective factors for delaying disease progression in HIV-1 infected Chinese LTNPs.