Preclinical diagnosis of cardiovascular diseases in workers engaged into industries with radiation danger
Takhauov, R.M.; Semënova, I.V.; Karpov, A.B.; Kubat, I.I.; Kretova, E.Iu.; Litvinenko, T.M.; Baranova, I.A.; Zhivova, E.Iu.; Popov, S.V.
Meditsina Truda i Promyshlennaia Ekologiia 2006(10): 1-7
2006
ISSN/ISBN: 1026-9428 PMID: 17136838 Document Number: 600587
The authors presented results of single-stage cross study of randomized select from a cohort of long seniority workers of isotope separation plant in Siberian Chemical Enterprise, with studies of inflammation markers, vascular and platelet he mostasis, serum lipid parameters, calculated atherogeneity coefficient, homocysteine levels. Serum atherogeneity coefficient and inflammation markers levels (fibrinogen, C-reactive protein) could be considered as the most informative laboratory indicators of underlying cardiovascular diseases in individuals without ischemic heart disease. Among a list of standard inductors of platelet aggregation, collagen and epinephrine should be considered preferential. Increased platelet aggregation requires disaggregant therapy, especially in smokers. Increased homocysteine level is associated with high frequency of atherosclerotic plaques and smoking.