Misoprostol for termination of second trimester pregnancy in a scarred uterus
Shammas, A.G.; Momani, M.D.
Saudi Medical Journal 27(8): 1173-1176
2006
ISSN/ISBN: 0379-5284 PMID: 16883447 Document Number: 600276
Objective: To investigate whether Misoprostol for mid-trimester pregnancy interruption in women with a scarred uterus has any adverse effects compared with those without a scar.Methods: During 5-year period from 2000-2004 at Queen Alia Military Hospital, Royal Medical Services, Amman, Jordan, a consecutive series of 520 women of 15-28 weeks of gestation who underwent termination of pregnancy were studied. Sixty-three patients had undergone at least previous one cesarean section and 457 served as control. Termination was undertaken using Misoprostol 400 mu g vaginally as a starting dose followed by 200 mu g vaginally every 6 hours, complications for each group were recorded.Results: The induction to abortion time was not significantly different in both groups (p=0.16); the median dosage was almost the same (p=0.31). The rate of incomplete abortion was significantly higher in the study group than control 82% versus 60% and 11.5% versus 6.1% for bleeding of more than 500 cc, while the rate of other complications was. almost the same.Conclusion: In the second trimester termination of pregnancy, the use of Misoprostol in women with previous single or multiple cesarean sections was not associated with excess complications.