Diabetic ketoacidosis in an HIV-infected patient undergoing antiretroviral therapy
Holm, M.R.; Hansen, B.R.øn.; Røder, M.E.
Ugeskrift for Laeger 168(9): 920-921
2006
ISSN/ISBN: 1603-6824 PMID: 16513058 Document Number: 600174
Following the introduction of highly active antiretroviral therapy (HAART), a number of metabolic and morphologic alterations, known as HIV-associated lipodystrophy syndrome (HALS), have been increasingly common in HIV-infected patients being treated with this therapy. The use of protease inhibitors (PI), in particular, has been associated with insulin resistance and hyperglycaemia, but only infrequently with diabetic ketoacidosis. We report a case of diabetic ketoacidosis in an HIV-infected woman after 1(1/2) years of a PI-containing regimen, demonstrating reduced beta cell function and insulin resistance.