Adverse reaction in a patient with aspirin-induced asthma treated with zafirlukast
Reyes-Balaguer, J.; Hernández de Rojas, D.
Journal of Investigational Allergology and Clinical Immunology 16(1): 69-70
2006
ISSN/ISBN: 1018-9068 PMID: 16599252 Document Number: 600114
Asthmatic patients receiving antileukotrienes may develop hypereosinophilia as a part of a Churg-Strauss syndrome. It is unclear if this effect is directly related to the administration of antileukotrienes or a consequence of the corticosteroid-sparing effect of antileukotrienes unmasking a Churg-Strauss syndrome. We present a case of hypereosinophilia related to zafirlukast therapy. The patient did not fulfil criteria for Churg-Strauss syndrome. Symptoms and laboratory findings improved after zafirlukast was removed.