Aspirin augments the concentration of endogenous hydrogen sulfide in mouse brain and liver
Srebro, Z.; Somogyi, E.; Wiliński, B.; Góralska, M.; Wiliński, J.; Sura, P.
Folia Medica Cracoviensia 47(1-4): 87-91
2006
ISSN/ISBN: 0015-5616 PMID: 18038616 Document Number: 599603
Intraperitoneal injections of lysine acetylsalicylate (L-ASA, aspirin) in a dose of 10 mg during 5 consecutive days to BALB/c and B10.PL mice increased the concentration of endogenous hydrogen sulfide in their livers. The rise of hydrogen sulfur levels was shown also in brains of BALB/c females and B10.PL males, however in BALB/c male brains there is no statistically significant difference. The mechanism of aspirin action on H2S concentration is discussed.