Pharmacokinetics-pharmacodynamics of antifungal drugs. Consequences for therapeutic drug monitoring
Jullien, V.; Lortholary, O.
Therapie 61(3): 209-217
2006
ISSN/ISBN: 0040-5957 PMID: 16989121 Document Number: 598184
Despite pharmacokinetic-pharmacodynamic relationships were clearly evidenced for antifungal drugs by the use of experimental models, few target plasma concentrations could be determined from studies performed in patients. The main causes explaining this lack of data are reviewed and the possible use in humans of the parameters obtained from animal models is discussed.