Susceptibility of fungi isolated from clinical materials to voriconazole
Pawlik, Bław.; Szul, A.; Macura, A.B.
Medycyna Doswiadczalna i Mikrobiologia 58(2): 155-161
2006
ISSN/ISBN: 0025-8601 PMID: 17133909 Document Number: 598008
The objective of the study was to evaluate the susceptibility of 139 fungal strains isolated from clinical materials to voriconazole, a new antifungal agent of the triazole group. A dilution method was used. The drug was incorporated into the culture medium at concentrations 0.1-100 mg/litre. It was found out that the antifungal effectiveness of the drug varied both between various fungal genera and species, and between strains within the same species. Total inhibition of the growth of 20% of the yeast-like fungi and 23.3% of the moulds was achieved at concentration 0.1 mg/litre. It was documented that the species Candida guilliermondii, C. kefyr, Saccharomyces cerevisiae and Aspergillus fumigatus, that as a rule are resistant to triazoles, were highly susceptible to voriconazole. Dermatophytes were also highly susceptible to the drug, particularly Trichophyton mentagrophytes and T. rubrum. The drug at concentration 0.1 mg/litre totally inhibited 73.5% of the dermatophytes, and at concentration 1 mg/litre - 97.0% of them were inhibited after 7 days incubation. After 14 days incubation, 97.0% of the strains were also inhibited at drug concentration not exceeding 1 mg/litre.