Tracing immature myelin in acute disseminated encephalomyelitis
Anlar, B.; Karli-Oğuz, K.; Yurtyapan, O.Y.üc.; Senbil, N.; Hergüner, O.; Altunbaşak, S.; Sönmez, F.M.üj.; Ozdemir-Geyik, P.
Turkish Journal of Pediatrics 48(3): 197-201
2006
ISSN/ISBN: 0041-4301 PMID: 17172061 Document Number: 597444
Inherent abnormalities of myelin have been suggested in the pathogenesis of multiple sclerosis (MS). We investigated myelin in acute disseminated encephalomyelitis (ADEM) patients by magnetic resonance spectroscopy (MRS) and cerebrospinal fluid (CSF) analysis for citrulline, a marker of immature myelin. A citrulline peak was observed in the normal appearing white matter of 7/15 patients and of 1/10 age-matched neurological controls (p=0.08). CSF citrulline was elevated in 4/6 patients. Alterations in the composition of myelin might predispose to or follow acute inflammatory disorders of the central nervous system.