Altered ability to learn of rat offspring with iodine deficiency
Tsintsadze, T.G.; Gabrichidze, G.O.; Lazrishvili, N.I.; Metreveli, D.S.; Mitagvariia, N.P.
Fiziolohichnyi Zhurnal 52(1): 82-88
2006
ISSN/ISBN: 2522-9028 PMID: 16553302 Document Number: 596975
Experimental data demonstrate that hypothyroidism could result in depressive behavior and subsequently thyroid hormones could act as antidepressants. Postnatal changes in learning ability, memory and emotional status in posterity of rats, which have experienced different level of iodine deficiency before conception and during all gestation period were investigated in this study. Results obtained suggest that sudden iodine deprivation before and during gestation led to a significant neurological defect, which was represented by loss of ability to learn, one of the most important functions of brain in newborn and by evidence of depression. Iodine supply to the diet of female rats eliminates these effects completely.