Use of combined treatment of rectal cancer involving metastases to regional lymph nodes
Barsukov, I.A.; Vlasov, O.A.; Tkachëv, S.I.; Nikolaev, A.V.; Tamrazov, R.I.; Malikhov, A.G.; Iskhagi, S.Kh.
Voprosy Onkologii 52(5): 521-524
2006
ISSN/ISBN: 0507-3758 PMID: 17168359 Document Number: 596767
N.N.Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow Use of combined pre- and intraoperative radiotherapy for rectal cancer involving metastases to regional lymph nodes failed to lower incidence of loco-regional recurrences or improve 5-year results, as compared with pre-operative radiotherapy alone. Besides, distant metastasis rates remained rather high (ca.30%). However, pre-operative radiotherapy plus local SHF-hyperthertnia were followed by a significant drop in loco-regional recurrence incidence (to 2.3%), as compared with surgery alone and combined treatment using pre-operative hyper-fractionated-radiotherapy (TTD 25 Gy). Distant metastasis rates dropped to 25%. Also, 5-year survival increased significantly.