Evaluation of a new third-generation ELISA for the detection of HIV infection
Yeom, J-Sup.; Lee, J-Beom.; Ryu, S-Ho.; Kang, H-Jung.; Kim, S.; Kim, Y-A.; Ahn, S-Young.; Cha, J-Eun.; Park, J-Won.
Annals of Clinical and Laboratory Science 36(1): 73-78
2006
ISSN/ISBN: 0091-7370 PMID: 16501240 Document Number: 596397
The purpose of this study was to assess whether the LG Anti-HIV 1/2 Plus ELISA ( LG Life Sciences, Seoul, Korea), a new third-generation enzyme-linked immunosorbent assay for the detection of HIV infection, has improved sensitivity and specificity in comparison to the other licensed third-generation assays. The sensitivity of the LG Anti-HIV 1/2 Plus ELISA was comparable to the Enzygnost Anti-HIV 1/2 Plus ELISA (Dade Behring, Marburg, Germany) (100% vs 100%), and it was capable of detecting highly divergent subtypes including HIV-1 group O. The specificity of the LG Anti-HIV 1/2 Plus ELISA was 100%. The concordance of the LG Anti-HIV 1/2 Plus ELISA and the Enzygnost Anti -HIV1/2 Plus was found to be 1. The LG Anti-HIV 1/2 Plus ELISA has a short window period among the third-generation ELISA assays and this test showed satisfactory reproducibility.