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Micronized diosmin (Detralex) for vein-related trophic ulcers: European experience

Savel'ev, V.S.; Pokrovskiĭ, A.V.; Sapelkin, S.V.; Bogachev, V.I.; Bogdanets, L.I.; Zolotukhin, I.A.

Angiologiia i Sosudistaia Khirurgiia 12(3): 53-60

2006

ISSN/ISBN: 1027-6661
PMID: 17641615
Document Number: 595796
The paper presents a meta-analysis of 5 large European studies (N - 723) on the micronized diosmin administration to patients with venous trophic ulcers (CEAP class VI). With the use of evidence-based approach, it was shown that micronized diosmin has a statistically significant clinical effect on middle-sized trophic ulcers (5 - 10 cm(2)) that persisted for 6 - 12 months. The study concludes that polyvalent venotonics are an appropriate and valuable addition to complex therapy of complicated chronic venous insufficiency.

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